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Our lab provides a new tool for detecting bone resorption with solid-state NMR

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Here, we focused on the mobile phase of the bone vascular system by carefully preserving moisture in adult Atlantic herring intermuscular bones. We detected pore water with high ionic strength and soluble degraded peptides whose  1 H-transverse relaxation times,  T 2 s, exceed 15 milliseconds. With favorable  T 2 s, we incorporated a solution state spinlock scheme into the INEPT techniques to unequivocally demonstrate collagen degradation. In addition, we detected a substantial amount of inorganic phosphate in solution with  31 P-NMR in the considerable background of solid hydroxyapatite calcium phosphate by saturation recovery experiment. It is consistent with the idea that bone resorption degrades bone collagen and releases calcium and phosphate ions in the pore water with increased ionic strength. Our report is the first to probe the resorption process in the heterogenous bone microstructure with a rigorous characterization of  1 H and  13 C relaxation behavior and direct assignment

Dr. A. Chekroun - Visiting Professor in our lab - : Pioneering Research in the Intersection of Biomathematics and Bone Research

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We were honored to host Dr. A. Chekroun, a Visiting Professor in our institution's Department of Physical Therapy. During his visit, Dr. Chekroun delivered thought-provoking talks highlighting the importance of interdisciplinary research and collaboration between biomathematics and bone research. Dr. Chekroun's pioneering work in biomathematics and bone research has led to significant advances in understanding bone remodeling and developing bone diseases. His expertise in nonlinear dynamics and mathematical modeling has allowed for the development of novel approaches that have revolutionized the field. Dr. Chekroun's visit provided a unique opportunity for students and faculty to engage with an expert in interdisciplinary research. His enlightening talks and presentations inspired us to think outside the box and pursue new research ideas. Dr. Chekroun's work highlights the importance of interdisciplinary research and collaboration between fields. His research has shown

Dr Berteau is an Acta Biomaterialia’s Outstanding Reviewers in 2021!

Dr Berteau receives the 2022 Outstanding Reviewer award for Acta Biomaterialia "Peer review is a cornerstone of science. Elsevier and Acta Materialia, Inc. are dedicated to supporting and recognizing the journals´ reviewers. The Acta Journals are delighted to announce the recipients of the 2022 Outstanding Reviewer awards for excellence in reviewing throughout the calendar year of 2021. These awards are selected by the Editors of Acta Materialia, Scripta Materialia, Acta Biomaterialia, and Materialia. Each recipient receives a certificate and is offered an honorarium as thanks for their support of the titles, as well as their help ensuring the continued high quality of the journals." Please find the full list of recipients here 

Our last publication in the Journal of Biomechanics depicts Subchondral bone alterations in a novel model of intermediate post traumatic osteoarthritis in mice

In Post Traumatic Osteoarthritis (PTOA), hypomineralization and increased remodeling of the Subchondral bone (SB) are the first stages of tissue alterations. Although these alterations are well depicted and one of the main targets in OA intervention, the link between SB compositional and mechanical properties alterations during OA progression remains scarce in the literature. Here, we hypothesized that SB shows – right after the first sign of gait pattern changes – a decrease in SB tissue formation depicted by (i) a decrease in thickness, (ii) a lower nanoscopic stiffness, and (iii) a decrease in mineral and collagen maturity. To test our hypothesis, we investigated PTOA in female C57Bl6 mice's right knee (n = 13 control group [CL] and n = 27 PTOA group) by using Gait Analysis, Histomorphometry, Nanoindentation, and Raman Spectroscopy (RS). We showed (i) an increased OA histological grade, (ii) a decrease in Cartilage and SB thickness, and (ii) an increase of stance time and stride

Berteau's Last publication in the Journal of Clinical Medicine presents Knee Pain from Osteoarthritis: Pathogenesis, Risk Factors, and Recent Evidence on Physical Therapy Interventions

For patients presenting knee pain coming from osteoarthritis (OA), non-pharmacological conservative treatments (e.g., physical therapy interventions) are among the first methods in orthopedics and rehabilitation to prevent OA progression and avoid knee surgery. However, the best strategy for each patient is difficult to establish, because knee OA's exact causes of progression are not entirely understood. This narrative review presents (i) the most recent update on the pathogenesis of knee OA with the risk factors for developing OA and (ii) the most recent evidence for reducing knee pain with physical therapy intervention such as Diathermy, Exercise therapy, Ultrasounds, Knee Brace, and Electrical stimulation. In addition, we calculated the relative risk reduction in pain perception for each intervention. Our results show that only Brace interventions always reached the minimum for clinical efficiency, making the intervention significant and valuable for the patients regarding thei

FULL PROGRAM : BONe InTerdisciplinary sympOSium 2022

Proud to organize with Laurent Pujo-Menjouet the BONe InTerdisciplinary sympOSium 2022 Leading experts in bone biomechanics Biology on the 20th of May at the College of Staten Island Full program Info free registration Knowledge is #free, BONITOS is #free.