BERTEAU Lab

We were honored to host Dr. A. Chekroun, a Visiting Professor in our institution's Department of Physical Therapy. During his visit, Dr. Chekroun delivered thought-provoking talks highlighting the importance of interdisciplinary research and collaboration between biomathematics and bone research. Dr. Chekroun's pioneering work in biomathematics and bone research has led to significant advances in understanding bone remodeling and developing bone diseases. His expertise in nonlinear dynamics and mathematical modeling has allowed for the development of novel approaches that have revolutionized the field. Dr. Chekroun's visit provided a unique opportunity for students and faculty to engage with an expert in interdisciplinary research. His enlightening talks and presentations inspired us to think outside the box and pursue new research ideas. Dr. Chekroun's work highlights the importance of interdisciplinary research and collaboration between fields. His research has shown ...

Dr Berteau receives the 2022 Outstanding Reviewer award for Acta Biomaterialia "Peer review is a cornerstone of science. Elsevier and Acta Materialia, Inc. are dedicated to supporting and recognizing the journals´ reviewers. The Acta Journals are delighted to announce the recipients of the 2022 Outstanding Reviewer awards for excellence in reviewing throughout the calendar year of 2021. These awards are selected by the Editors of Acta Materialia, Scripta Materialia, Acta Biomaterialia, and Materialia. Each recipient receives a certificate and is offered an honorarium as thanks for their support of the titles, as well as their help ensuring the continued high quality of the journals." Please find the full list of recipients here 

In Post Traumatic Osteoarthritis (PTOA), hypomineralization and increased remodeling of the Subchondral bone (SB) are the first stages of tissue alterations. Although these alterations are well depicted and one of the main targets in OA intervention, the link between SB compositional and mechanical properties alterations during OA progression remains scarce in the literature. Here, we hypothesized that SB shows – right after the first sign of gait pattern changes – a decrease in SB tissue formation depicted by (i) a decrease in thickness, (ii) a lower nanoscopic stiffness, and (iii) a decrease in mineral and collagen maturity. To test our hypothesis, we investigated PTOA in female C57Bl6 mice's right knee (n = 13 control group [CL] and n = 27 PTOA group) by using Gait Analysis, Histomorphometry, Nanoindentation, and Raman Spectroscopy (RS). We showed (i) an increased OA histological grade, (ii) a decrease in Cartilage and SB thickness, and (ii) an increase of stance time and stride...

For patients presenting knee pain coming from osteoarthritis (OA), non-pharmacological conservative treatments (e.g., physical therapy interventions) are among the first methods in orthopedics and rehabilitation to prevent OA progression and avoid knee surgery. However, the best strategy for each patient is difficult to establish, because knee OA's exact causes of progression are not entirely understood. This narrative review presents (i) the most recent update on the pathogenesis of knee OA with the risk factors for developing OA and (ii) the most recent evidence for reducing knee pain with physical therapy intervention such as Diathermy, Exercise therapy, Ultrasounds, Knee Brace, and Electrical stimulation. In addition, we calculated the relative risk reduction in pain perception for each intervention. Our results show that only Brace interventions always reached the minimum for clinical efficiency, making the intervention significant and valuable for the patients regarding thei...

Proud to organize with Laurent Pujo-Menjouet the BONe InTerdisciplinary sympOSium 2022 Leading experts in bone biomechanics Biology on the 20th of May at the College of Staten Island Full program Info free registration Knowledge is #free, BONITOS is #free.

2. CUNY College of Staten Island Average Net Price: $5,118 Private or Public: Public Highest Salary After Attending: $94,579 The College of Staten Island is grounded in centuries-old traditions of learning, teaching, research, and service. It is committed to the highest standards in the field of academic excellence. The college has competitive and rigorous programs across its undergraduate, graduate, and professional divisions. Programs are designed to allow students to fulfill their creative & educational aspirations. It offers affordable tuition rates, flexible time-frames for completion, access to a variety of scholarships, and a warm community of motivated peers. The entry-level degree required for physical therapists is a Clinical Doctorate of Physical Therapy (DPT). CSI CUNY has offered this degree since 1995. The program promises an excellent clinical foundation with a CUNY tuition and the opportunity of a rewarding career as a physical therapist after graduating from this p...

Congratulations to  Abdennasser Chekroun, Laurent Pujo-Menjouet, Steve Falcoz, Kamyine Tsuen and Kevin Yueh-Hsun Yang for capturing  the behavior of the bone GRN part that controls mineralization by using a mathematical model. BerteauLAB team provided  in this new article  an advanced review of empirical evidence about interactions between gene coding (i) transcription factors and (ii) bone proteins. These interactions are modeled with nonlinear differential equations using Michaelis-Menten and Hill functions. Compared to empirical evidence - coming from osteoblasts culture -, the two best systems (among 12 6 =2,985,984 possibilities) use factors of inhibition from the start of the activation of each gene. It reveals negative indirect interactions coming from either negative feedback loops or the recently depicted micro-RNAs. The difference between the two systems also lies in the BSP equation and two ways for activating and reducing its production. Thus, it hig...